The clinical and pathological findings of entric drainage (ED) v/s. bladder drainage (BD) in pancrease transplantation is still contraversial. In this study, early outcome and histologic findings of these two methods were compared. In an exprimental animal model, in animal laboratory of Shiraz university of medical sciences, 16 dogs after diabitization were randomly divided into two groups. In the first group, pancrease was transplanted with entric drainage and in second group, pancrease transplantation with bladder drainage was done. Early clinical and pathological outcomes were evaluated. Data was analyzed in SPSS 13 software with Mann-whitney test. Mean survival was 10.6 (range, 5-20) days for group 1 and 14.4 (range, 3-23) days for group 2 (p>0.05). Fasting blood suger values(FBS) before transplant were 279 +/- 26.8 mg/dl v/s. 278 +/- 41.6 mg/dl (P>0.05). Two weeks after transplantation, serum FBS decreased to 84.9 +/- 2.9 v/s 84.2 +/- 0.98 (p>0.05). Serum amylase in BD and ED groups were 378.5 +/- 328 v/s 422.6 +/- 54.7 mg/dl, respectivly (p>0.05).Early leakage was not found in dogs with BD. However, 37.5% of dogs with ED developed early leakage (p<0.05).Clinical and pathologic pancraetic necrosis occured in 37.5% of dogs with BD v/s. 62.5% of dogs with ED (p>0.05). Although Early outcome of these methods (ED v/s BD) was statistically similar, early complications of dogs with ED was more than those with BD.