The success of a transplantation program depends upon the quality and effectiveness of the donation process, whereby the key role is assigned to the local procurement transplant coordinator (TxC). This important professional figure was only recently established in Greece. The local TxC’s duties were outlined alongside those of the Hellenic Transplant Organization (H.T.O.) foundation in 1999, whereby three different transplant coordinator positions, Clinical, Central and Local were specified. In 2002 the above mentioned were legally consolidated. The professionals had to be doctors or nurses already working in ICU and had to be appointed by the Hospital and the ICU directors in each hospital as requested by the H.T.O. By the end of 2004, this network consisted of 122 TxC’s located in 74 ICU’s, especially trained on donation procedures and ethics. Furthermore, the board of directors of H.T.O. decided that in 2005 there be closer cooperation between the 45 most donor generating ICU’s and their TxC’s. It was decided that the local TxC’s would work part time and receive an H.T.O. monthly grant. Professionally, 70% were doctors and 30% nurses. Half of the doctors were ICU directors, specially appointed to influence the ICU personnel. The 45 ICU network started in 2005, resulting in an increase of 154% in potential donor referrals and a 33% and almost 38% increase in actual donors and transplantation procedures respectively, compared to 2004. This substantial increase achieved by the institution TxC’s network was considered satisfactory. Higher goals were set for the future.