Since 1995, the Hospital de la Santa Creu i Sant Pau (HSCSP) has been running an educational programme on organ and tissue donation and transplantation for high school students. The main objective is to promote organ and tissue donation. The programme is designed as a four hour session: a general talk by a transplant coordinator about donation and transplantation processes, a talk by a nephrologist about dialysis versus kidney transplantation, interviews with already-transplanted patients; finally, students visit and talk to waiting list patients during dialysis. The objective of this work was to evaluate the impact of this program according to the teachers who attended these sessions with their pupils. A total of 368 sessions were performed over 11 years (October 1995 - June 2005). A total of 5168 students from 31 schools participated in the programme. Teachers answered a short questionnaire that was sent out in March 2005. Scoring on a one to ten scale, they were asked to evaluate programme contents, course dynamics and students satisfaction. All 31 questionnaires sent to teachers at the 31 participating schools were answered (100%). The average score concerning programme content was 9.06 (range 7-10), for course dynamics it was 8.84 (range 6-10), and for student satisfaction it was 8.65 (range 5-10). This educational program on organ and tissue donation for transplantation is highly considered and a good strategy to educate high school students. Similar programs could be implemented at high schools worldwide.