After decades of organ transplantation, main problem is still shortage of donors. In many European countries, 'presumed consent” rule has facilitated the process. In our country that informed consent should be obtained from the first relatives of deceased donors, the problem is complicated. To overcome this problem, based on Shiite cleric’s Fatwa, we established a local Network in southern Iran. Kidney transplantation program was started in 1988 in Shiraz when the national organization for organ procurement has not been founded yet. For 3 years, kidney transplantation was performed only with living donors. In 1992, the first consent was gained from a deceased donor family. Between 1988 and 1993, we were able to obtain only six consents. Liver transplant program started in 1993. To increase the donation, we began educating ICU, ER, and neurosurgery wards nurses, neurosurgeons, anesthesiologists, and neurologists of our province and 7 other neighbor provinces in southern Iran. The necessity, diagnosis and reporting of deceased donor were discussed. These sessions were repeated every 6 months or yearly. First consent from a deceased donor family was obtained in 1992. During 7 years (1992-8), only 21 out of 128 deceased cases (16.4%) were harvested. In 1998, we educated 7 transplant coordinator nurses and one-hundred staff nurses for 7 other provinces. Sixty neurosurgeons, anesthesiologists, and neurologists, working in 20 cities, had several seminars about transplantation and brain-death. The consents rate increased from seven in 1998, to 12 in 1999, and to 243 between 2000 and 2005 (each year around 40 consents). In the last two years, 67% of deceased donor families issued consents for organ donation. Repeated education of ICU, neurosurgical and ER nurses, neurosurgeons, anesthesiologists, and neurologists is helpful in increasing the issued consent rates form deceased donor families and cooperation between the transplant wards.