Living kidney donation and more specifically living unrelated is common in Iran. In 2005, 1721 (89%) kidneys for transplantation were from living donors and 209 (11%) were procured from heart-beating brain dead donors.Considering high living kidney donation rate (25 PMP) and in order to find out the motivations and donors` feeling following donation, this study was conducted. 345 living kidney donors (20%) were studied in viewpoint of various characteristics using a questionnaire. Findings are analysed by SPSS. Donors were 82% male and 18% female. Mean age was 27 +/- 0.34 (Mean +/- SD). Donors were related to recipients in 10% and in 90% they were unrelated. Motivation for donation was purely financial in 60%, financial plus altruistic components in 34% and 6% was purely altruistic. Donors` feeling following donation and before discharge of hospital was complete satisfaction in 95%, relative satisfaction in 3%, 0.3% regretful and 1.7% indifferent. Kidney transplantation among renal replacement therapies owning to increase in life expectancy, improve in quality of life and as the cheapest modality (after the first year of Tx) has remarkable significance.Since cadaveric kidney donation does not supply all the ever-increasing needs, living kidney donation should be considered seriously under defined and transparent circumstances. Being based on clear legal basis, governmental incentive, supervision, donors` long-term support and follow-up should be the main requirements of this rewarding donation programme.