Renal Transplantation Recipients (RTRs) are in Increased Risk For The Cancers, Most Frequently Skin SCC and BCC. In Contrast the Other Countries, Sarcom Kaposi (SK) and Non- Hodjkin Lymphoma (NHL) are Particularly a problem in Eastern Asian Countries, that its Cause is the Prevalence of Antibody Against HPV-8 (Following Infection with HPV). Therefore it's Important to Find Risk Factors for Development of Cancers, in RTRs. Genetic Factors (Particular HLA) are Involved in the Development of Cancers. We Performed a Study, Retrospectively, in Labbafinejad Hospital (IRAN); on 44 Patients that had PKTM (Especially SK and NHL), From 1985–2002. We Evaluated Frequency of Different HLA in These Cases and Compared them With Control Cases (RTRs without Malignancy). We Tried to Select the Control Cases as the same as Malignancy Cases. After our Observations; Below Obtained: (Patient Divided in 2 Groups, Malignancy Cases (MC) and Without MC (WMC). The Mean Age of MC Was 43.5 Years and WMC was 43 Years. Of All Patients in MC Group; 15 Cases were SK, 13 Cases NHL and 6 Cases SCC and 10 Cases were different. The Average Interval Between Transplantation and Malignancy Incidence was 15.3 Month. Our Findings about HLA Antigen in RTRs, Suggest HLA-CW4 is Sensitive in SK (P.Value = 0.025, Chi- Square = 4.96). And about HLA-A9 and HLA-DQ1 in SK, HLA-A3 in NHL and HLA-A3; HLA-DR4; HLA-DR53 and HLA-DQ3 in SCC, we need to Study more Cases and Perform the Other Studies.