The wide spectrum of clinical manifestations in cytomegalovirus (CMV) disease necessitates laboratory exams for confirmation of correct diagnosis. We tried to find the accuracy of correct diagnosis factors that enhance the proper diagnosis of patients of CMV disease in clinically suspected kidney recipients by nephrologists.
Between 2002 and 2005 in Baqiyatallah Hospital, Tehran, Iran, We retrospectively reviewed 127 cases with the clinical diagnosis of CMV disease and investigated the final diagnosis. Patients with positive pp65 considered as true CMV disease. the rate of proper diagnosis and correlated factors were assessed. The rate of proper diagnosis of CMV disease was 23.6%. Mean age at diagnosis was 48.87 ± 15.37 years. Mean duration between transplantation and the diagnosis was 4.59 ± 11.56 months. Proper diagnosis had correlation with higher age at transplantation and history of diabetes mellitus (p=0.01). This relationship was not seen for gender, educational level, socioeconomic status, history of graft rejection and blood transfusion (p>0. The results showed that more than 75% of clinically suspected of CMV disease actually don’t have the disease. The correct clinical diagnosis in kidney transplanted patients with clinical evidence of CMV disease, attention to 2 simple factors including age at transplantation and history of diabetes mellitus could add to accuracy of correct diagnosis.