Acute rejection remains an important cause of graft loss after renal transplantation. However, the influence of functional immune response gene polymorphism on transplant outcomes remains controversial. A total 100 first adult kidney recipients on cyclosporinebased immunosuppression were genotyped for IL-10 (-1082 G/A), TNFα (-308 G/A) and IFN-γ (+874 T/A) single nucleotide polymorphism by ARMS-PCR. An acute rejection episode was defined based on clinical and histological findings (Banff criteria). Multivariate analysis showed no significant association between acute rejection and single nucleotide polymorphisms in IL-10, TNFα genes or dinucleotid repeat polymorphisms in IFN-γ gene. Our results demonstrated that cytokine gene polymorphisms did not influence the early outcome of kidney transplantation.