Donor shortage is still major problem of transplantation programs. Even in a country with a system or an organization for transplantation, the rates of gained consents in different areas are not the same. At our center, we obtained informed consent for kidney and liver transplantation programs since 1988 and 1993, respectively. At beginning, we encountered with difficulty of gaining consents from deceased donor families. We undertook this study to evaluate factors influencing consent rate from the deceased donor families. Between 1988 and 2006, 1555 kidney and 253 liver transplantations were performed in our center. During this period, 243 consents were obtained from the deceased donor families. Data of age, sex, residential place, number of family members, marital status, education, cause of brain death, and religious beliefs was collected. Statistical analysis performed by student T and Chi squire tests. Informed consent was obtained from 243 deceased donors (158 males, 85 females), with a mean age of 29.4 years. 175 (72%) of cases had less than 30 years. 167 (68.7%) were single. 56 (23%) were younger than 15 years. 17 cases (6.9%) were older than 50. Cause of brain death in 209 cases (86%) was vehicle accident. Families of 8 (88%) brain death cases of 9, issued consent in private hospitals. All families of donors with suicide attempts issued consent. 183 brain death cases were from rural or suburb areas, from whom 168 (92 %) consents was obtained. 63% of cases had not academic education. less consent was obtained from crowded families than small ones (40% versus 60%, P<0.05).Issued consents from singles, young cases, suicidal victims, patients admitting private hospitals, those with small families, or live in rural areas were higher than consents obtained from donors of large cities, married or those admitted in charity hospitals.