Restlessness and psychomotor agitation are among the causes of morbidity and mortality in different diseases. They are known problems in ESRD patients but no study have ever evaluated their presence and effects in kidney recipients. This study aimed to explore the presence of restlessness and psychomotor agitation and their relation with morbidity of patients after renal transplantation.Sixtyone subjects were randomly selected from kidney transplant recipients being followed in Baqiyatallah Hospital, Tehran, Iran. Restlessness and psychomotor agitation were determined by Hospital Anxiety Depression Scale (HADS). The correlation of these scores with demographic data, clinical data, sexual function, marital adjustment, quality of life, sleep quality and comorbidity of patients was evaluatedRestlessness and psychomotor agitation were presented in 60 (98.36%) of patients. Their scores were significantly correlated with age at transplantation (r=0.269, p= 0.04 and r=0.324, p= 0.01 respectively), total score of comorbidity (r=0.273, p=0.02 and r=0.257, p=0.04 respectively), role limitation due to emotional problems (r=-0.26, p=0.03 and r=-0.25,p= 0.04 respectively) and mental health (r= -0.277, p=0.02 and r=-0.252, p=0.04 respectively). There was no correlation between these symptoms and gender, marital status, and sexual relationship score of patients (p>0.05). Restlessness and psychomotor agitation are frequent and can impose high degrees of morbidity on renal transplant recipients. Proper management of these problems seems to improve different aspects of quality of life in these patients.