The prevalence of psychiatric comorbidities such as depression and anxiety are somewhat high after kidney transplantation. Nonetheless, few studies have assessed the impact of depression and anxiety on morbidity in kidney transplant recipients. The aim of this study was to investigate the effects of depression and anxiety on post-transplant morbidity.In a cross sectional study in Baqiyatallah Hospital between the years 2005 and 2006, 88 kidney transplant recipients were evaluated for the presence of depression and anxiety according to HADS (Hospital Anxiety Depression Scale), and patients were divided to Group Ia (with anxiety, n=24) and Group IIa (without anxiety, n=64). According to the depression scores of HADS, patients were also categorized into Group Id (depressed, n=20) and Group IId (non-depressed, n=68). In order to measure morbidity of each patient, scales of quality of life (Short Form-36), marital adjustment (Revised Marital Adjustment Scale), sexual relationship (Relationship and Sexuality Scale) and quality of sleep (Pittsburgh Sleep Quality Index) were used. Different morbidity measures were compared in groups of anxious versus non-anxious and also depressed versus non-depressed.Comparing group Ia with group IIa, presence of anxiety was correlated with a poorer mental health (44.45±7.80 vs 48.80±7.14, p=0.01), general health (42.91±16.67 vs 49.36±12.77, p=0.05), marital adjustment (48.35±16.62 vs 55.13±8.01,p=0.04) and more sleep disturbances (1.66±0.63 vs 1.36±0.62, p=0.05). Depressed subjects, compared with non-depressed ones, reported more fatigue (46.84±8.85 vs 39.79±8.30, p=0.002) and poorer sexual relationship (19.00±5.92 vs 15.28±5.50, p=0.03). Anxiety and depression are among causes of higher morbidity in kidney transplant recipients. Appropriate treatment of these comorbidities may improve quality of life, quality of sleep, marital relation and sexual relationship.