This study analysed factors affecting engraftment in autologous peripheral blood stem cell transplantation. Fifty-four patients with lymphoproliferative disorders were treated from March 2000 to April 2006. There were 37 males and 17 females, with a median age of 43 years (range 12–60). The cohort included 13 Hodgkin’s lymphoma, 31 non-Hodgkin’s lymphoma, and 10 multiple myeloma cases. The median number of infused CD34+ was 1.7 _ 106 per kg. (0.38–15).The medians for ANC and PLT engraftment were 12 days (10–15) and 11 days (6–33), respectively. The CD34+ cell dose correlated significantly with platelet engraftment (p=0.0001). The CD34+ cell dose and timing of G-CSF administration had no significant influence on ANC engraftment (p=0.3 and p=0.05, respectively). The results imply that the CD34+ cell dose is the most important predictor of haematopoietic engraftment, namely PLT engraftment. The other factors studied had no clear influence on engraftment kinetics in this cohort.