Castleman’s disease (Angiofollicular Lymphoid Huperplasia) is a lymphoproliferative process thought to be mediated by IL-6 overexpression.
Castleman’s disease has 2 variants: hyaline –vascular type and plasma cell variant. (Multicentric castlemans disease). Hyaline vascular type tend to be localized while plasma cell variant has more systematic signs and carriers worse clinical prognosis.
Castlemans disease is associated with B-Cell lymphoma & KS. Also HHV8 & ۧ.
Castlemans disease have been described thrice post kidney tx.
In this report, we document the course of renal tx recipient who developed the plasma cell variant of castlemans disease 16 months after failure of his allograft & return to dialysis. He who had clinical resolutgion of this complication often tx nephrectomy.
To our knowledge this is the first case where the disease manifestations disappered after graft removal. Our patient had a chronic renal allograft rejection this could have driven all the systematic manifestations of MCD and possibly reactivated a latent HHV-8 infection. In this case the immunohistochemical testing for HHV-8 is not available to prove a role for this agent.