Patients with hepatitis C infection who are candidates for renal transplantation, could do transplantation if hepatitis C are inactive and don,t have liver cirrhosis. After renal transplantation due to immunosupression, hepatitis C virus could again reactivate and causes progression of liver disease and also cause kidney transplant involvement (glomerulonephritis, rejection). The purpose of this study was evaluation of results of renal transplantation in patients with past history of hepatitis C involvement, which had done kidney transplantation in Razi hospital belongs to gilan university of medical sciences. This is a crosssectional study of 14 patients with past history of hepatitis C among 60 patients who, all had passed one year after kidney transplantation, since 1998 up to 2001. 10 among 14 patients had done liver biopsy before transplantation, but one year posttransplantation they didn't agree to repeat it. HCV-RNA was negative in patients at the time of transplantation and after that. Immunosuppressive drugs protocol consisted of: prednisolone; ciclospori; azathioprine; mycophenolate mophetile. These 14 patients were compared with the rest of the recipient (46 persons) (HCV- negative), for patient survival, graft function, and liver function tests, at one year post kidney transplantation. Cryoglobuline was negative in patients with past history of hepatitis C. Data were analyzed by spss-10. One year after transplantation no detrimental effects were seen in those patients with past history of hepatitis C on liver and transplanted kidney. Patient and graft survival was good. One year after transplantation HCVRNA was negative. Rejection were seen in 4 out of 14 patients with hepatitis C. No glomerulonephritis were seen posttransplantation. The mean plasma creatinine was 1.18 mg/dl. Immunosupressive drugs side-effect were not seen on liver of these 14 patients. Only two among 14 patients died because of cardiovascular problems and cytomegalovirus infection.
This study showed that short term consequences in our patients with past history of hepatitis C infection in comparison with those who are not infected with hepatitis C, one year post-transplantation, is generally good. Although this study was done in a short time after transplantation, but in order to know precisely the impact of hepatitis C on recipient of kidney transplantation the evaluation needs to be continue in the future.