Renal Transplantations (RT) are carried out more than 1700 cases annually in Iran. Mostly of them designed to compute the burden of RT as a criterion for a health problem or condition to be considered as public health issue in Iran in 2004. WHO’s practical guide of national burden of disease studies had been used for conducting the study. Five steps had been performed, diagramming natural history & dynamic modeling of the diseases, data gathering from Management Center for ransplantation of Ministry of Health, computing the local disability weight of RT, data analyzing with DISMOD II and computing the Disability Adjusted Life Year (DALY). Years Life Lost (YLL), Years Lived with Disability (YLD), and DALY was 717.9, 6217.6, and 6935.5 years, respectively. DALY per case and per 100.000 populations was 4 and 10.4 years respectively. Over 69.5% and 68.1% of DALY of RT were seen in male and female with 20-44 years old respectively. However, this burden in this age group needs to be confirmed by cohort or case controlled studies. The DALY per 100.000 male populations was higher compare to female population (12.5 years versus 8.3 years). It is recommended to design and conduct studies to define the causes or factors associated with low incidence cases of RT in females. Since, RT meets the criteria for a public health issue in Iran; primary prevention, early detection and screening of CKD’s initiation factors such as diabetes, and hypertension are recommended for health policy makers. Is Living Unrelated Donor Transplantation (LURD).