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Volume: 4 Issue: 2 December 2006 - Supplement - 1

FULL TEXT

TIME-DEPENDENT VARIATION IN THE URINE OUTPUT AFTER RENAL TRANSPLANTATION

Diuresis soon begins after renal transplantation. Although controversial, early post kidney transplant urine volume may be correlated with a favourable short and long term graft survival. The aim of the present study was to figure out any possible correlation between the first month serum creatinine and the early and late urine outputs in the renal transplant recipients.: In a cross sectional and prospective study, daily urine volume was measured at 24 and 48 hours, and one month after renal transplantation as well as the mean first month serum creatinine in the patients with stable kidney function and without the evidence of allograft rejection (n =54). Fifteen patients were also followed for their urine output at least 6 months post kidney transplantation. Data are expressed in mean +/- SD. Statistical analysis was performed by SPSS 11.0 using ANOVA. Correlation was made using Pearson test. P value was set at 0.05. Mean age of the kidney allograft recipients was 35.5 +/- 12.1, with a male to female ratio of ~ 1.3. The mean first month serum creatinine was 1.26 +/- 0.4 mg/dl. The mean urine outputss were 7.97 +/- 5.07, 5.45 +/- 3.05 and 3.44 +/- 1.25 L at 24 and 48 hours and one month after renal transplantation. Those patients who followed for six months posttransplantation were found to have a mean urine volume of 3.20 +/- 1.24 L at the end of this period. This trend shows that urine volume steadily decreases from 24 and 48 hours to one month after renal transplantation (P < 0.05). However, the urine volumes were rather comparable at one month and 6 months after transplantation (P > 0.05). A positive correlation was found between the first-month serum creatinine and the urine volume at one month (r = 0.302 and P = 0.035) but not at 24 and 48 hours and six months post-transplantation (P > 0.05). Urine volume is stablized by one month after the renal transplantation where it is positively correlated with the first-month serum creatinine. Hence, one may conclude that in a stable renal allograft recipient, the final urine output is related to the early graft function.



Volume : 4
Issue : 2
Pages : 132


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