Prevalence of inflammatory bowel disease (IBD) post-renal transplant is affected by the immune tolerance and modality of immunosuppression used. Mycophenolate mofetil (MMF) may have a promoting effect in developing post transplant erosive enterocolitis and Crohn’s disease-like pattern of colitis. A 40 years old gentleman who developed end stage renal disease due to chronic glomerulonephritis and commenced on haemodialysis for two months till he received live unrelated renal transplant. He developed early post transplant diabetes mellitus and graft rejection which responded to methyl prednisolone pulse and OKT3 treatment. He was maintained on prednisolone, MMF and tacrolimus. Three years after transplant, he developed mild constitutional symptoms, mouth ulceration and chronic intermittent bloody diarrhea. Colonscopy showed active segmental colitis with aphthous ulcers involving the proximal descending colon and the splenic flexure. Colonic biopsies showed distended and branched crypts in the ascending colon, moderate active chronic colitis with regenerative atypia, skipping appearance and ulceration in the splenic flexure and descending colon. Edematous crypts with ulceration in the sigmoid colon and rectum. Features were highly suggestive of Crohn’s disease. He was treated successfully with high dose steroids and 5-aminosalicylic acid. Subsequently, he developed chronic transplant glomerulopathy and restarted on haemodialysis. Denovo Crohn’s disease can develop in renal transplant recipients in spite of immunosuppressive therapy especially when MMF is used.