This study was designed to determine the value of heart auscultation and physical examinations in detection of Valvular Heart Disorders (VHD) in End Stage Renal Disease (ESRD) patients. Ninety-seven patients from a central hemodialysis department in Esfahan were studied for determining the diagnostic value of routine physical examination (RPE) and heart auscultation (HA) in detection of VHD. Patients underwent RPE and HA. RPE included precordidial and abdominal examinations. Two dimensional (2D) and M mode colored Doppler echocardiography was performed in all the patients as gold standard for detection of the VHD in this study. Valvular Heart Disorders was cathegorised as Aortic, Mitral, Tricuspid and Pulmonary artery stenosis, regorgitation or insufficiency. Each person was examined by a cardiologist and then was tested by other cardiologist for echocardiography, the results of RPE and HA was compared with the results of echocardiography. The sensitivity and specifity of RPE in detection of VHD was 50 and 92 percent respectively. Only one patient had aortic stenosis (AS) in echocardiography that was correctly diagnosed by RPE. The specifity of RPE in diagnosis of AS was about 98 percent. The sensitivity of PRE in diagnosis of aortic insufficiency (AI) was about 11 percent and its specifity was 92 percent. Large number of patients without any murmur or with functional murmur had VHD in the echocardiography. None of the patients had tricuspid or mitral stenosis and pulmonary valve disorders. There was a significant difference between diagnosis by PRE and echocardiography (p value<0.01). According to results of this study we conclude that detection of VHD in ESRD patients cannot be made only by RPE and HA and echocardiography is necessary. Routine echocardiography in regular intervals is recommended for detecting Valvular Heart Disorders in ESRD patients.