This study conducted to determine the frequency of Valvular Heart Disorders (VHD) in End Stage Renal Disease (ESRD) patients in a referral hemodialysis center in Esfahan. This cross sectional study was performed in order to determine the frequency of VHD in ESRD patients aged 47± 17(Mean± SD) in a referral hemodialysis center in Esfahan during 1997. Ninty nine patients (58 male and 42 female) under went two dimensional, M mode and colored Doppler echocardiography during first 24 hours after hemodialysis. The patients has been hemodialysed 3-12 hours per week for about 77(4+745) weeks before the study. Sixty point one percent of the patients had at least one type of VHD. Valvular heart disorders consisted of functional disorders, calcification or thickening of the valves rings.Valvular regurgitations were the most findings. Mitral and Tricuspid regurgitation (MR and TR) in 4 percent, TR, MR and Aortic Insuuficiency (AI) together in 3 percent. AI and MR together in 2 percent and TR in one percent of cases were detected. Only one of the patients had valvular stenosis that was aortic stenosis (AS). Anatomical valvular changes as thickening, calcification or both without any functional abnormality were diagnosed in 8.1 percent of the patients. There were no pulmonary valve abnormalities and tricuspid and mitral stenosis. The results of this study show high frequency of VHD in ESRD patients in our study. These results suggest appropriate planning for prevention, early detection and treatment of VHD is ESRD patients.