This study was conducted to determine Parathyroid hormone abnormalities and its correlation with Valvular Heart Disorders (VHD) in End Stage Renal Disease Patients (ESRD) patients. Eighty ESRD patients (46 male, 34 female) aged 47+/- 17(Mean +/- SD) who referred to one of the main hemodialysis centers in Esfahan were studied. The blood level of paraththyroid hormone (PTH) was tested. The records of seventy one of the patients were reviewed for blood level of Calcium (Ca) and Phosphorous (P). Ca and p level had been measured before and after hemodialysis during last six month. All of the patients underwent 2D, M mode and Colored Doppler Echocardiography during first 24 hours after hemodialysis. Different VHD were recorded and the patients divided in two groups: with and without VHD, according the results of echocardiography. PTH level of about 88.8 percent of the patients was higher than normal. PTH level did not show significant differences in two groups. Hypercalcemia and hypocalcemia was found in, seven and twenty-four person respectively, sixty-two patients had hyperphosphatemia and the others were normal. There was weak correlation between PTH and P levels (r=0, P value <0.01). Ccorrelation between PTH and Ca levels was not significant. Blood Ca and P levels tested before and after hemodialysis. Ca*p and PTH level were not difference in two groups. The results of this study could not show any correlation between Ca,P and parathyroid hormone (PTH) disorders with VHD, but they show the high frequency of PTH disturbance, hyperphosphatemia and hypocalcemia in ESRD patients in our study. These results confirm the necessity of planning for prevention, diagnosis and control of hyperparathyroidism in our ESRD patients.