Ophthalmological complications in transplanted patients are often due to underlying disorders or long term drug use. Retinal complications in transplant reciepients can be one of the following: A) Infectious B) Microvascular retinopathy C) Thrombocytopenia, anemia and hyperviscosity due to cytotoxic drugs D) Central serous chorioretinopathy (CSCR) often occurs after solid organ transplantation and is probably related to high dose steroid, stress, hypertension and cyclosporine. Case report: A 36 years old man was readmitted three weeks after renal transplantation because of acute rejection. He was treated with methylprednisolone for 3–5 days. On the second day he complained of left eye blurred vision that was begun from one week ago. Physical exam showed that visual acuity of left eye was 4/10 and there was macular edema. After 8 days the right eye became blurred. With the impression of CSCR, fluorescin angiography was done and CSCR was confirmed (figure 1-3). Steroid was tapered more rapidly. He was followed up for 3 months and visual acuity improved gradually and reached 10/10, so no laser therapy was needed. In this case, under treatment with cyclosporine and prednisolone, CSCR was developing and high dose steroid usedto treat acute rejection accelerated the complication (CSCR) resulted in severe visual loss.