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Volume: 4 Issue: 2 December 2006 - Supplement - 1

FULL TEXT

CHARACTERISTICS OF LONG TERM LIVE DONOR RENAL ALLOGRAFT RECIPIENTS WITH NO REJECTION EPISODES

Kidney transplantation is the treatment of choice for patients with end stage renal disease. Long term renal allograft survival is improving despite the high risk of complications and rejection. This study included 189 renal allograft recipients who had functioning graft for 10 years or more; out of which 101 patients had no previous rejections (study group) and 88 had previous rejection episodes (control group). The two groups were compared regarding different variables. The mean age of rejection free patients was 31 years and that of the control group was 28 years (P=0.013). Male recipients constitute 62% of the study group versus 77% of control group (P=0.027). Donor gender and age showed no significant difference. The study group showed significantly fewer HLA (A&B) mismatches than control group (P=0.012). DR matching showed no significant difference. Renal allograft function was significantly better in the study group (P=0.001). Long term complications developed in both groups however only hypertension was significantly more common in the control group. Diabetes and infection were more common in the non rejector group but the difference was not significant. Multivariate analysis revealed significant impact of recipient gender, age and post transplant hypertension. Renal transplantation despite long term complications and rejection has provided 10 years or more of near normal life. The most important characteristics of rejection free long term survivors included female gender, recipient age, HLA (A&B) matching and development of post transplant hypertension.



Volume : 4
Issue : 2
Pages : 102


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