IMPACT OF NONE- AND DELAYED GRAFT FUNCTION ON PATIENTS’ SURVIVAL
Sienko J1, Wisniewska M2, Tejchman K1, Sulikowski T1, Romanowski M1, ZietekZ1, Kaminski M1, Pabisiak K2, Ostrowski K1, Mierski A1
1Department Of General Surgery And Transplantation, Pomeranian Medical University, 2Department Of Nephrology, Transplantology And Internal Diseases, POLAND
The rertospective study surveyed 442 patients after kidney transplantation. Awere performedyears 1990-1995 i 2 Stettin centres: Department of Surgery and Transplantation, Pomeranian Acadmey of Medicine and Deaprtment of Surgery, Provincial Hospital in Szczecin. Study population was divided in 3 groups; criterion for the division was graft function:
IGF group (immediate graft function) – 312 patients;
DGF group (delayed graft function) – 107 patients;
NGF (none graft function) – 23 patients.
Factors connected with none graft functions immediately after transplantation were separated for further statistical analysis. The effect of this action was connection of both groups DGF and NGF (107+23=130 patients). As immediate graft function we defined situation, when patient did not need dialysis after transplantation, what was connected with gradual normalisation of creatinine and potassium levels and appearance of efffective diuresis. Moment of back to permanent dialysis schedule or graft explantation was border time of graft function. We observed 1-year patient survival in IGF, DGF, NGF groups: 87,8%, 72,9%, 65,2%, and graft survival respectively: 92,3%, 87,0%, 0,0%; 3-year patient survival: 79,8%, 65,4%, 60,9% and graft survival: 83,5%, 76,5%, 0,0%; 5-year patient survival: 76,6%, 62,6%, 60,9% and graft survival: 73,9%, 65,5%, 0,0%. Comparing Kaplan-Meier equilibrium for patients from groups IGF, DGF and NGF survival we obsserved statistically significant differences between them (p < 0,017). Log-rank test showed significantly longer time of survival in IGF group than in DGF group (p < 0,048). According to Cox model risk of death in DGF group was 1,47 time higher than in IGF group in one-factor analysis and 1,59 time higher in multifactor analysis (p < 0,019). So DGF appearance was independent risk factor of patient’s death. In view of small numer of patients In NGF group we did not show significant differences in patients survival comaparing with IGF and DGF group. In groups IGF, DGF i NGF. Significance of differences DGF and NGF comparing with IGF was analysed with chi2 test. Appearance of DGF is independent risk factor of patients’ death comparing with patients with immediate graft function.