Cardiovascular diseases are the main causes of morbidity and mortality in kidney transplant recipients. Hyperhomocystenemia up regulates collagen synthesis and accumulation by arterial smooth muscle cells & plays an important role in the development of arteriosclerosis in the general population & transplanted patients. We decided to check the possible relevance between serum homocystein (HCY) level and carotid intima-media thickness (IMT) (a predictor of premature atherosclerosis) in renal transplant recipients. The study was performed on 33 clinically stable renal transplant recipients and 19 healthy persons. All subjects underwent ultrasonographic measurements of carotid IMT. Analyzed clinical & biochemical parameters included: age, sex, mean arterial blood pressure (MAP), pulse pressure (PP), duration of transplantation, lipid profile, Bun, Cr, Uric acid. The two analyzed groups did not differ in respect to age and BMI. Mean HCY level in transplanted group (21.03+/-13.84) was significantly higher than control (10.94+/-7.17) (P<0.001). Mean carotid IMT in transplant recipients (0.82+/-0.69) was significantly higher than control group(0.69+/-0.18)(p<0.001). MAP, and PP were significantly higher in the renal transplant recipients group when compared to the control group. IMT & hCY level was positively correlated with duration of transplantation(r=0.44; p=0.004) in the patients group. But there weren’t positive correlation between HCY level & age with carotid IMT in both groups. In our study there wasn’t any positive Correlation between carotid intima-media thickness & serum Hcy level in renal transplant recipients. May be the effect of other factors on IMT are prominent.