Polymorphism of the gene encoding components of the renin-angiotensin system (Ras) represent an area of intense research of cardiovascular disease associations, Numerous studies have addressed the role of Ras gene polymorphism in the development and progression of renal disease. Also, it has been reported that patients with ACE DD and angiotensinogen AGT (AA) genotypes are associated with poorer chronic allograft dysfonction (CAD). We investigated the effects of gene polymorphisms of the renin-angiotensin system (Ras) including angiotensin converting enzyme (ACE) angiotensinogen (AGT) angiotensin 1 receptor (ATR1) and aldosterone synthase (CyP11B2) in renal transplant patients (88 males and 58 females; mean age 29 + 10.5 years). Genotypes were determined using polymerase chain reaction (PCR) sequence specific primers and PCR following by RFLP analysis. Renal allograft recipients with chronic allograft dysfonction (CAD) had significantly lower frequencies of the MM genotype than those without CAD (P< 0.05). The other Genetic polymorphism of the Ras were not associated with CAD. This study provides that determination of AGT M 235 T genotypes before transplantation may help identily patient who are at risk for chronic renal transplant dysfonction.