Poor patient compliance is common during dialysis therapy. We aimed to study incidence of noncompliance, contributing factors, effects on quality of life(QOL) among cadaveric renal transplantation waiting list patients. We included 86 renal transplantation waiting list patients (56M/30F). Dialysis duration, previous renal transplantation history, comorbid conditions, interdialytic weight gain, predialysis BUN, creatinine, potassium, and phosphate were recorded. Noncompliance criteria was skipping>1 dialysis session or shortening a dialysis session>10 min in 1 month, interdialytic weight gain>5.7 of body weight, predialysis serum potassium>6 mEq/L, phosphate level>7.5 mg/dl. There were 49 noncompliant (age: 46.8±21.8 years, HD duration:83.9±48.7 months) and 37 compliant(age:42.8±12.1 years, HD duration:96.5±45.2 months) patients. QOL was evaluated by short form-36 and depression levels by Beck Depression Inventory. Previous renal transplantation was present 24.4% and comorbid diseases were 31.3% in all patients. Depressive patients had 77.8% comorbid diseases. No difference was found between the groups considering age, gender, dialysis duration, previous transplantation history and co-morbid diseases (p>0.05). Noncompliant patients had lower QOL (p<0.04). Noncompliant patients had higher degree of depression (p=0.01). QOL and Beck scores were negatively correlated (p=0.001, r=-0.561). Noncompliance to diet and dialysis therapy is associated with depression which further decreases QOL in renal transplantation waiting list patients. Early diagnosis of depression is possible by monitoring noncompliance and therapeutic intervention may benefit during the transplantation waiting period.