The popularity of fast-track (FT) anesthesia has risen significantly since the 1990s. This type of anesthesia can reduce hospital costs, reduce complications associated with mechanical ventilation, and shorten intensive care unit (ICU) and hospital stays. Although many centers now use FT anesthesia for cardiac surgery, this method is not commonly used for liver transplantation. This study investigated one center’s experience with FT anesthesia in patients who had undergone liver transplantation. The medical charts and anesthesia records of 12 patients who had undergone elective liver transplantation with fentanyl (3-5 mcg/kg/hr) anesthesia (control group) were retrospectively reviewed, and the results were compared with 27 patients who received remifentanil (0.1-0.2 mcg/kg/min) anesthesia (FT group). Patients who were unconscious preoperatively and who received more than 100 ml/kg of blood products were excluded. Preoperative evaluation of the patients included complete blood count, coagulation profile, serum biochemistry, and radiologic studies. For each case, the amount of RBC, whole blood, FFP, albumin transfusions and fluids administered were recorded. Intraoperative hemodynamic variables, and core temperature were noted. Other data collected were duration of mechanical ventilation, extubation time, postoperative hemodynamic status, pulmonary complications, and lengths of ICU and hospital stays. Patients were extubated when they were awake, hemodynamically stable, and breathing spontaneously. Demographic and peroperative data of the patients were similar in both groups. The mean extubation times in the FT and control groups were 1.8±2.8 and 36.1±15.8 hrs, respectively. (p<0.05). The groups had similar ICU and hospital stays (ICU stay: 83.0±48.7 and 98.5±47.6 hrs for the FT and control groups, respectively; hospital stay: 548.0±604.5 and 616.2±313.5 hrs, respectively). The rates of postoperative complications were also similar. Although the differences were not statistically significant, the results suggest trends toward shorter ICU and hospital stays for patients who undergo liver transplantation with FT anesthesia.