Hepatitis C virus (HCV)-infected hemodialysed patients often display an impaired immune response, exemplified by leukocyte dysfunction, and defects in chemotaxis and phagocytosis. These are associated with leukocyte activation, reflected by the release of inflammatory cytokines and by the modified levels of cell surface adhesion receptors. Two important adhesion molecules are responsible for granulocytes function, L-selectin a member of selectin family expressed on leukocytes, and Mac-1, a member of the integrin family that bind to the endothelial cells following shedding of L-selectin from the cell surface. Infection with HCV is also known to upregulate certain adhesion molecules, which suggest a role for HCV in the immunologic consequences of uraemia and hemodialysis. This study aims to explore whether bio-incompatibility response in HCV infected patients undergoing intermittent hemodialysis are different from those of uninfected patients as regard the leuko cytic expression of L-selectin (CD62L), Mac-1 (CD11b) and serum levels of soluble L-selectin. Study subjects comprised 24 HCV-infected and 12 HCV-uninfected haemodialysed patients. While changes in L-selectin and Mac-1 expression were not significantly different between HCV-positive and HCV-negative patients, significant differences were seen in the expression of L-selectin (168.5 ± 41.9 vs. 151.4 ± 40.3, p < 0.001) and Mac-1 (348.0 ± 74.6 vs. 377.4 ± 78.7, p < 0.001) at the start of vs. 15 min after commencement of dialysis, respectively. In conclusion, while no statistically significant differences was recognized in granulocytes expression of L-selectin and Mac-1 in HCV infected patients compared to uninfected patients under hemodialysis, these results indicate that in addition to phenotypic changes induced by hemodialysis, other modifiable factors related to HCV infection should be considered in future studies.