Kidney transplantation in patients with end stage renal disease is an effective renal replacement therapy. The quality of life in kidney transplant recipients is higher than those on hemodialysis. However, the higher risk of infection due to immunosuppressive therapy, especially one year after renal transplantation, can result in death or other complications. We conducted a prospective and cross-sectional study to evaluate the incidence of infection six months after renal transplantation on 287 recipients. Thirty-one patients who returned to dialysis status after graft failure or did not have regular follow up were excluded. One hundred and seventy nine cases (70%) were male and 77 patients (30%) were female. One or several infectious events occurred in 71%. Incidence of infection was higher among old patients (60-70yrs) whereas, young group (20-30 yrs) had lower incidence rates. Forty-one percent of infection episodes were seen in the first month and the rest were observed two to six months after renal transplantation. Infections have seen 6 months after renal transplantation included: urinary tract infection (62%), upper and lower respiratory tract infections (16.5%), mucocutaneous infections (4.2%) and the others (5.8%). The most common urinary pathogens were E coli (45%), pseudomonas (16%) and coagulase negative staphylococci, (11.3%) respectively. In conclusion, post renal transplant infection in six months after surgery was frequent and UTI was the most common cause of it. Thus, 6-12 months antimicrobial prophylaxis is recommended to prevent UTI.