Cardiovascular disease is one of the main causes of morbidity and mortality in recipients of renal transplants. Many studies have demonstrated a strong association between elevated plasma total homocysteine (tHcys) level and serum c-reactive protein (CRP) with cardiovascular disease. A total of 32 Transplanted recipients (22 men, 10 women) were investigated. tHcys level were elevated in 25 (78.1%) Transplanted patients with mean level of 18.12 6.3 Plasma tHcys correlated with time after transplantation (P<0.01) and folate supplementation P<0.05. No significant correlations were found between tHcys level and age, gender, and plasma values of creatinine, total cholesterol, Triglycerides, HDL-cholestrol, LDL-Cholestrol. CRP increased only was seen one patient. Mean level of CRP was (1.78 3.5) mg/L.
Most patients received treatment with statins.
Conclusion: we conclude that a moderate degree of hyperhomocysteinemia is often present in renal Transplant and that folate supplementation with statins must be considered in this population.