Cardiovascular complications are main causes of mortality in chronic renal failure and kidney transplantation. Hyperlipidemia plays a main role. Hyperlipidemia causes accelerated atherosclerosis and glomerulosclerosis and allograft dysfunction. In this study we assess 42 patients (16 woman and 26 man) with first time kidney transplantation and without other medical problem like as diabetes mellitus and obesity from 1996 to 1999.these patients had normal allograft function and received cyclosporine, prednisolone and azathioprine.4 week after kidney transplantation hypercholesterolemia and rising LDL was observed in 34.2% of patients which was more common in female and reduction of triglycerid and VLDL level was observed in 20% of patients. 5 months after kidney transplantation augmentation of total cholesterol was detect in 51.7% and increase of triglycerid level in 41% of patients which was more common in female. Evaluation effect of HMG-CoA reductase inhibitor drug (Lovastatin) in hyperlipidemic patients revealed reduction of total cholestrol and LDL. Lovastatin had no effect on triglycerid and VLDL level.