Traditionally, liver transplantation (LTx) has consisted of a total native hepatectomy that included retrohepatic inferior vena cava (IVC). The Belghiti method consists of a recipient hepatectomy with preservation of the native retrohepatic IVC and a subsequent side-to-side caval anastomosis. We present our experience with both techniques (traditional vs. Belghiti) to determine significant clinical differences between them. We performed the traditional (n=120) and Belghiti LTx (n=110) in 201 patients. The data concerning operation and anastomosis time (h:mm), cold storage time (h:mm), blood loss(ml), intraoperative transfused packed red blood cells(RBC) and fresh-frozen plasma (FFP), the number of re-LTx and deaths were compared. The data are presented as mean (*=p<0.05). LTx Technique Op time Anas time Cold time Blood loss Traditional (n=120) 7:35 1:39 9:23 1980 Belghiti(n=110) 5:19* 0:41* 5:39* 1150* LTx Technique RBC FFP Re-LTx Deaths Traditional(n=120) 5.3 14.5 20 10 Belghiti(n=110) 1.5* 7.9* 9* 3* Using Belghiti technique the time of surgery, anastomosis and cold storage, blood loss and the substituted RBCs and FFPs could be reduced significantly. The technique has reduced the duration of the anhepatic phase as well as the need for venous bypass. Clinical outcome and quality of LTx could be improved using Belghiti LTx technique.