The aim of this study was to evaluate at what extent early outcome of renal allograft function is related to HLA class I antigen matching. Live kidney transplantation (LKT) recipients were selected and matching in four antigens of HLA-A and B loci between donor-recipient and its influence on graft function was observed. Results 115 subjects on triple drug immunosuppression were selected. In 46%, 33% and 21% recipients, kidney donors were parents, siblings and others respectively. When recipients at the end of one month were divided in sub-groups of normal renal function (NRF) and impaired renal function (IRF) (SCr > mol/l), there was no difference in_175 number of HLA antigen & loci match, cytotoxic cross match and pattern of graft dysfunction in these two groups. In another comparison at the end of first week between normal graft function (NGF) and impaired graft function (IGF) (SCr > mol/l) there was no difference in HLA antigen pattern or matching_145 number. Renal allograft function in the early post-transplant period depends on several factors and from this observation it is concluded that HLA class I antigen match may not have any added influence on early graft outcome in live kidney transplantation.