GVHD is one of the most frequent complications of bone marrow transplantation (BMT) and recently renal involvement has been described as a manifestation of chronic GVHD, Such as thrombotis microangiorpthies, membranous nephropathy, and focal segmental glomerulosclerosis. Here we report a case of BMT with ANCA associated glomerulonephritis. A 29-year-old man who received allograft bone marrow transplantation for chronic myeloid leukemia after preparation with chemotherapy. After BMT, he developed acute and chronic GVHD that was improved by steroid. After withdrawal of therapy and about 10 months after BMT, he developed nephrotic nephritic syndrome and serum creatinine increased (1.7 mg/dl). P-ANACA was detected in his serum. Histology of renal biopsy tissue showed focal segmental proliferative glomerulonephritis with glomerulosclerosis in 20% of available glomerulus and large cellular crescents in 6% of glomerulus. There was no staining immunoglobulins and complements along the capillary walls. Electron microscopy showed no immune deposits. After prednisone therapy, the proteinuria gradually decreased and p-ANCA was negative. These findings suggest the ANCA associated glomerulonephritis in this patient is related to renal involvement in the course of chronic GVHD.