In order to predict rejection in renal transplantation by immune parameters, 16 kidney transplant candidates (4 female and 12 male, age 20-65 years, first time transplant) were selected, none of them had diabetes. Immune parameters such as lymphocytes, immunoglobulines and complements before transplantation, during acute rejection episodes and after recovery of renal function were measured by flow cytometry. The results showed that IgE, IgA and IgG after transplantation were lower than before transplantation. It was the result of immunosuppressive drugs in these patients, IgM increased after transplantation. The amount of C3 was increased due to decreasing of consumption of C3 in the body. Also other immune parameters were compared in patients without rejection episode (n=9 group 1) and those with rejection episode (n =7 group 2). The results showed that IgE, CD3, CD4, CD8 and CD4/CD8 levels in group 2 were higher than group 1(p<0.05). The level of IgA, C3 and C4 in group 2 were lower than group 1(p<0.05). There was no difference in immune parameters between two groups before transplantation. Therefore these parameters can be used for prediction of rejection. When the rejection episode was treated, there was no significant difference in these parameters in two groups.