Owing to using immunosuppressive (IS) drugs, renal transplant recipients are at risk for malignancies including Kaposi sarcoma (KS). Following the diagnosis, physicians tend to decrease the dosage of immunosuppressive drugs to lower tumour progression rate. On the other hand, this measure may prone the patient to acute rejection. In this study we evaluated the outcome of KS and renal allograft following discontinuation or decreasing the dosage of IS drugs. During a 12-year period, 14 (9 males and 5 females) out of 1699 cases of renal transplantation diagnosed as KS. In 11 patients, cyclosporine was completely discontinued, and the dosage was decreased to half of initial dose in other cases. Except one case, we discontinued either azathioprine or mycophenolate mofetil. During 57 months of follow-up on average, serum creatinine level remained normal in ten, but increased in 4 cases. Two out of these 4 patients had deteriorated kidney function at the beginning of study. Three cases died due to myocardial infarction and septicaemia, while having normal serum creatinine. Discontinuation of immunosuppressive drugs caused complete remission of Kaposi Sarcoma in all patients except one that received chemotherapy. Discontinuation of IS drugs following the diagnosis of KS caused complete remission of this cancer in almost all patients and seems to be relatively safe for kidney graft function.