Kidney recipients are at a risk of developing cancer after transplantation. This is a retrospective study of the incidence, types, and outcome of post kidney transplantation cancer at a single centre. More than 1450 kidney recipients came under the care of Kuwait transplantation team. The records of recipients who left the country soon after transplantation (Tx) were excluded from the study. The records of the remaining 1171 recipients were retrospectively reviewed. They were 724 males and 447 females, aged 3 to 76 at the time of Tx. They received kidney grafts from 968 living, and 203 cadaveric donors. Different induction and maintenance immunosuppression protocols were used. 50 recipients developed cancer after Tx. They were 29 males and 21 females, aged 16 to 65 at the time of Tx. Their grafts were obtained from 44 living, and 6 cadaveric donors. They had 54 malignant lesions with an incidence of 4.6%. Malignant lesions were: 11 lymphoma, 9 Kaposi’ sarcoma, 7 squamous cell carcinoma, 2 basal cell carcinoma, 1 Bowen’s disease, 4 breast carcinoma, 4 thyroid cancer, 3 renal cell carcinoma, 2 brain cancer, and 9 more lesions. Lesions appeared at 4 to 288 months after Tx (mean 85.6 months). 29 recipients died with functioning grafts at 4 days to 60 months (mean 12.4 months) after diagnosis of cancer. 6 patients lost their grafts and returned to dialysis therapy at 1 to 34 months (mean 9.2 months) after cancer detection. 15 recipients are alive with functioning graft for 6 to 160 months (mean 65.2 months) after detection of cancer. The incidence of post Tx cancer in the present series is smaller than that reported in the literature. Lymphoma and skin cancer (Kaposi’ sarcoma and SCC) were the common types. Cancer can appear as early as 4 months or as late as 288 months after Tx. The prognosis is quite good in cases of skin, thyroid and colon cancer, and is very poor in cases of lymphoma, breast, and liver cancer.