The greatest benefit of LDLT should not undermine the concern for the donor safety. The aim is to evaluate the outcome in donors after right lobe liver donation in Egypt (Dar Alfouad Hospital, DAFH). Fifty LDL resections were performed in the period (2001-2004), 34 were men and 16 women. Mean age was 29.2+6.4 years. The residual liver volume was 32-51.2% (41.1+4.5%). Mean operative time was 560+62.2 min, the ICU stay was <24h except in 2 donors stayed 3-9 days and the mean hospital stay was 15.4+7.7 days while the mean follow up was 6 months. There was no mortality. Major complications occurred in 5 donors (10%), including intra-operative bleeding required transfusion of 3 units of PRBcs in (1), Biliary leak in (2) managed by ERCP & ultrasonographic guided aspiration of biloma) and pneumonia in (2). Minor complications included mild pleural effusion in 13 donors (26%), intra-abdominal collection in 3 (6%) managed by ultrasonographic guided drainage, transient ascites in 10 (20%), wound infection in one case (2%) and mild depression in 7 donors (14%). One donor readmitted for ultrasonographic guided aspiration of subphrenic collection. The residual liver volume did not affect the rate of complications. No one required re-operation. Normalization of the liver functions occurred after a mean period of 14 days. Return to pre-donation activity occurred within 6-8 weeks and with no liver impairment during the period of follow up. Safety of the living donors is the main in LDLT. Major complications occurred in 10% of our series.