Liver Transplantation has been done exclusively throughout Iran and some neighbouring countries in our center for 11 years. Potential recipients from all over the country or neighbouring countries are selected for the waiting list based on the established indications for liver transplantation. The first 130 consecutive liver transplantations performed between April 14, 1993 and June 26, 2004, in Shiraz (Southern Iran) organ transplant centre were evaluated retrospectively using the liver transplantation database, with a minimum follow-up period of 6 months. Among 130 consecutive recipients, 61% were male, and 39% were female (M/F=1.36). The average recipient age was 27.4 ± 11.5 years (range: 9 months to 58 years). Mean cadaver age was 24.2±9.5 which is significantly lower than similar reports. 122 patients had a full-size cadaveric transplant; others received partial graft. The operative procedure was performed in a standard manner using duct-to-duct anastomosis in 68% of the cases; piggyback technique was utilized in 90%, venovenous bypass in the rest. All cases were first transplants. Immunosuppressive regimen included Celcept (Azathioprine for first 10 cases), cyclosporine and methylprednisolone. IV cyclosporine _was used for induction in the first 39 cases and since then enteral preparation is used to avoid complications. Major causes of liver failure included cryptogenic (36%), Wilson’s disease (16%), and viral (14%). 80% of the patients were in class C Child-Pugh classification. Mean duration of hospitalization was 29.4±14.2 days (range= 17-84). Rejection occurred in 27% of cases once and 8% twice. Just one primary non-functioning graft occurred. Most common short-term complications included respiratory (12%), neurologic (10%) and biliary (10%). Long-term complications included rejection (9%) renal failure (6%) and death (15%). The 1-, 2-, and 3-year patient survival rates were 92%, 89%, and 85%, respectively.