Acute rejection (AR) represents one of the most dangerous complications following solid organ transplantation. The liver is known to be the most tolerogenic organ, due to the large amount of immune cells endowed in its stroma, able to exert an extraordinary immunomodulatory effect via the interaction with host immune system. Therefore, in liver transplant (LT) setting AR is not a major issue any more and clinical practice has shown that mild and moderate AR does not need any additional immunosuppression (IS). In some cases, even severe AR may spontaneously recover. We report about 12 cases of spontaneous resolution of severe AR in LT. Five other cases were excluded given the exitus for causes unrelated to lack of treatment. Indication to LT were: HCV (5), alcoholic (3), HBV (2), cryptogenic (1), HBV+HCV (1). AR occurred at postoperative day 7 (10 patients) and 30 (1). One patient developed AR six years after LT, following an attempt of weaning from IS. In all cases, adaptation of ongoing IS simple strict clinical surveillance or reintroduction of previous immunosuppressant doses lead to prompt recovery. Late routine liver biopsies failed to demonstrate any signs that could be related to previous episodes of AR. We conclude that severe AR might not need any further additional treatment, when trend of clinical setting is towards an improvement, even if slow. Close surveillance is mandatory.