Key words : Acute kidney injury, End stage renal disease, Global health, Health equity, Social determinants of health

Introduction

Kidney disease is a global public health problem that affects more than 750 million persons worldwide.¹ The burden of kidney disease varies substantially across the world, as does its detection and treatment. Although the magnitude and impact of kidney disease is better defined in developed countries, emerging evidence suggests that developing countries have a similar or even greater kidney disease burden.²

In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors, leading to significant disparities in disease burden, even in developed countries.³ These disparities exist across the spectrum of kidney disease—from preventive efforts to curb development of acute kidney injury (AKI) or chronic kidney disease (CKD), to screening for kidney disease among persons at high risk, to access to subspecialty care and treatment of kidney failure with renal replacement therapy (RRT). World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. In this editorial, we highlight these disparities and emphasize the role of public policies and organizational structures in addressing them. We outline opportunities to improve our understanding of disparities in kidney disease, the best ways for them to be addressed, and how to streamline efforts toward achieving kidney health equity across the globe.

Burden of kidney disease
Availability of data reflecting the full burden of kidney disease varies substantially because of limited or inconsistent data collection and surveillance practices worldwide (Table 1).⁴ Whereas several countries have national data collection systems, particularly for end-stage renal disease (ESRD) (e.g., United States Renal Data System, Latin American Dialysis and Renal Transplant Registry, and Australia and New Zealand Dialysis and Transplant Registry), high-quality data regarding nondialysis CKD are limited, and often the quality of ESRD data is quite variable across settings. This situation is of particular concern in low-income countries. For example, a meta-analysis of 90 studies on CKD burden conducted across Africa showed very few studies (only 3%) with robust data.⁵ The provision of adequate resources and a workforce to establish and maintain surveillance systems (e.g., screening programs and registries) is essential and requires substantial investment.6 Incorporating kidney disease surveillance parameters in existing chronic disease prevention programs might enhance global efforts toward obtaining high-quality information on kidney disease burden and attendant consequences.

In addition to a need for functional surveillance systems, the global importance of kidney disease (including AKI and CKD) is yet to be widely acknowledged, making it a neglected disease on the global policy agenda. For instance, the World Health Organization (WHO) Global Action Plan for the Prevention and Control of Non-Communicable Diseases (NCDs) (2013) focuses on cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes but not kidney disease, despite advocacy efforts by relevant stakeholders such as the International Society of Nephrology and the International Federation of Kidney Foundations through activities such as World Kidney Day. This situation is quite concerning because estimates from the Global Burden of Disease study in 2015 showed that around 1.2 million people were known to have died of CKD,⁷ and more than 2 million people died in 2010 because they had no access to dialysis. It is estimated that another 1.7 million die from AKI on an annual basis.^8,9 It is possible, therefore, that kidney disease may contribute to more deaths than the 4 main NCDs targeted by the current NCD Action Plan.

Risk factors for kidney disease
Data in recent decades have linked a host of genetic, environmental, sociodemographic, and clinical factors to risk of kidney disease. The population burden of kidney disease is known to correlate with socially defined factors in most societies across the world. This phenomenon is better documented in high-income countries, where racial/ethnic minority groups and people of low socioeconomic status carry a high burden of disease. Extensive data have demonstrated that racial and ethnic minorities (e.g., African Americans in the United States, Aboriginal groups in Canada and Australia, Indo-Asians in the United Kingdom, and others) are affected dispro-portionately by advanced and progressive kidney disease.^10–12 The associations of socioeconomic status and risk of progressive CKD and eventual kidney failure also have been well described, with persons of lower socioeconomic status bearing the greatest burden.^13,14

Recent works have associated apolipoprotein L1 risk variants^15,16 with increased kidney disease burden among persons with African ancestry. In Central America and Southeastern Mexico, Mesoamerican nephropathy (also referred to as CKD of unknown causes) has emerged as an important cause of kidney disease. While multiple exposures have been studied for their potential role in CKD of unknown causes, recurrent dehydration and heat stress are common denominators in most cases.¹⁷ Other perhaps more readily modifiable risk factors for kidney disease and CKD progression that disproportionately affect socially disadvantaged groups also have been identified, including disparate rates and poor control of clinical risk factors such as diabetes and hypertension, as well as lifestyle behaviors.

Diabetes is the leading cause of advanced kidney disease worldwide.¹⁸ In 2016, 1 in 11 adults worldwide had diabetes and more than 80% were living in low- and middle-income countries¹⁹ where resources for optimal care are limited. Hypertension is also estimated to affect 1 billion persons worldwide²⁰ and is the second leading attributed cause of CKD.18 Hypertension control is important for slowing CKD progression and decreasing mortality risk among persons with or without CKD. Hypertension is present in more than 90% of persons with advanced kidney disease,¹⁸ yet racial/ethnic minorities and low-income persons with CKD who live in high-income countries have poorer blood pressure control than their more socially advantaged counterparts.²¹

Lifestyle behaviors, including dietary patterns, are strongly influenced by socioeconomic status. In recent years, several healthful dietary patterns have been associated with favorable CKD outcomes.²² Low-income persons often face barriers to healthful eating that may increase their risk of kidney disease.^23–25 People of low socioeconomic status often experience food insecurity (i.e., limited access to affordable nutritious foods), which is a risk factor for CKD26 and progression to kidney failure.²⁷ In low-income countries, food insecurity may lead to undernutrition and starvation, which has implications for the individual and, in the case of women of child-bearing age, could lead to their children having low birth weight and related sequelae, including CKD.²⁸ Rates of undernourishment are as high as 35% or more in countries such as Haiti, Namibia, and Zambia.²⁹ However, in high-income countries, food insecurity is associated with overnutrition, and persons with food insecurity have increased risk of overweight and obesity.^30,31 Further, food insecurity has been associated with several diet-related conditions, including diabetes and hypertension.

Acute kidney injury
AKI is an underdetected condition that is estimated to occur in 8% to 16% of hospital admissions³² and is now well established as a risk factor for CKD.³³ Disparities in AKI risk are also common, following a pattern similar to that observed in persons with CKD.³⁴ AKI related to nephrotoxins, alternative (traditional) medicines, infectious agents, and hospitalizations and related procedures are more pronounced in low-income and lower-middle-income countries and contribute to increased risk of mortality and CKD in those settings.³⁵ Importantly, the majority of annual AKI cases worldwide (85% of more than 13 million cases) are experienced in low-income and lower-middle-income countries, leading to 1.4 million deaths.³⁶

Health policies and financing of kidney disease care
Because of the complex and costly nature of kidney disease care, its provision is tightly linked with the public policies and financial status of individual countries. For example, gross domestic product is correlated with lower dialysis-to-transplantation ratios, suggesting greater rates of kidney trans-plantation in more financially solvent nations. In several high-income countries, universal health care is provided by the government and includes CKD and ESRD care. In other countries, such as the United States, ESRD care is publicly financed for citizens; however, optimal treatment of CKD and its risk factors may not be accessible for persons lacking health insurance, and regular care of undocumented immigrants with kidney disease is not covered.³⁷ In low-income and lower-middle-income countries, neither CKD nor ESRD care may be publicly financed, and CKD prevention efforts are often limited. In several such countries, collaborations between public and private sectors have emerged to provide funding for RRT. For example, in Karachi, Pakistan, a program of dialysis and kidney transplantation through joint community and government funding has existed for more than 25 years.³⁸

In many settings, persons with advanced CKD who have no or limited public or private sector funding for care shoulder a substantial financial burden. A systematic review of 260 studies including patients from 30 countries identified significant challenges, including fragmented care of indeter-minate duration, reliance on emergency care, and fear of catastrophic life events because of diminished financial capacity to withstand them.³⁹ Authors of another study conducted in Mexico found that patients and families were burdened with having to navigate multiple health and social care structures, negotiate treatments and costs, finance their health care, and manage health information.⁴⁰ Challenges may be even greater for families of children with ESRD, because many regions lack qualified pediatric care centers.

Organization and structures for kidney disease care
The lack of recognition and therefore the absence of a global action plan for kidney disease partly explains the substantial variation in structures and capacity for kidney care around the globe. This situation has resulted in variations in government priorities, health care budgets, care structures, and human resource availability.⁴¹ Effective and sustainable advocacy efforts are needed at global, regional, and national levels to get kidney disease recognized and placed on the global policy agenda.

In 2017, the International Society of Nephrology collected data on country-level capacity for kidney care delivery using a survey, the Global Kidney Health Atlas,⁴ which aligned with the WHO’s building blocks of a health system. The Global Kidney Health Atlas highlights limited awareness of kidney disease and its consequences and persistent inequities in resources required to tackle the burden of kidney disease across the globe. For example, CKD was recognized as a health care priority by government in only 36% of countries that participated in this survey. The priority was inversely related to income level: CKD was a health care priority in more than half of low-income and lower-middle-income countries but in less than 30% of upper-middle-income and high-income countries.

Regarding capacity and resources for kidney care, many countries still lack access to basic diagnostics, a trained nephrology workforce, universal access to primary health care, and RRT technologies. Low-income and lower-middle-income countries, espe-cially in Africa, had limited services for the diagnosis, management, and monitoring of CKD at the primary care level, with only 12% having serum creatinine measurement, including estimated glomerular filtration rate. Twenty-nine percent of low-income countries had access to qualitative urinalysis using urine test strips; however, no low-income country had access to urine albumin-to-creatinine ratio or urine protein-to-creatinine ratio measurements at the primary care level. Across all world countries, availability of services at the secondary/tertiary care level was considerably higher than at the primary care level (Figure 1A and B).^4,42

Renal replacement therapies
The distribution of RRT technologies varied widely. On the surface, all countries reported having long-term hemodialysis services, and more than 90% of countries reported having short-term hemodialysis services. However, access to and distribution of RRT across countries and regions was highly inequitable, often requiring prohibitive out-of-pocket expenditure, particularly in low-income regions. For instance, more than 90% of upper-middle-income and high-income countries reported having chronic peritoneal dialysis services, whereas these services were available in 64% and 35% of low-income and lower-middle-income countries, respectively. In comparison, acute peritoneal dialysis had the lowest availability across all countries. More than 90% of upper-middle-income and high-income countries reported having kidney transplant services, with more than 85% of these countries reporting both living and deceased donors as the organ source. As expected, low-income countries had the lowest availability of kidney transplant services, with only 12% reporting availability, and live donors as the only source.

Workforce for kidney care
Considerable international variation was also noted in the distribution of the kidney care workforce, particularly nephrologists. The lowest density (<5 nephrologists per million population) was very common in low-income countries, whereas the highest density (>15 nephrologists per million population) was reported mainly in high-income countries (Figure 2).^4,43,44 Most countries reported nephrologists as primarily responsible for both CKD and AKI care. Primary care physicians had more responsibility for CKD care than for AKI care, as 64% of countries reported that primary care physicians are primarily responsible for CKD care and 35% reported that they are responsible for AKI care. Intensive care specialists were primarily responsible for AKI in 75% of countries, likely because AKI is typically treated in hospitals. However, only 45% of low-income countries reported that intensive care specialists were primarily responsible for AKI, compared with 90% of high-income countries; this discrepancy may be due to a general shortage of intensive care specialists in low-income countries.

The appropriate number of nephrologists in a country depends on many factors, including need, priority, and resources, and as such there is no global standard with respect to nephrologist density. Regardless, the demonstrated low density in low-income countries calls for concern as nephrologists are essential to provide leadership in kidney disease care, and a lack of nephrologists may result in adverse consequences for policy and practice. However, it is quite encouraging that the number of nephrologists and nephropathologists is rising in low-income and lower-middle-income countries, in part thanks to fellowship programs supported by international nephrology organizations.45 It is important to note that the role of a nephrologist may differ depending on how the health care system is structured. The density statistic merely represents the number of nephrologists per million population and provides no indication of the adequacy to meet the needs of the population or quality of care, which depends on volume of patients with kidney disease and other workforce support (e.g., availability of multidisciplinary teams).

For other care providers essential for kidney care, international variations exist in distribution (availability and adequacy). Overall, provider shor-tages were highest for renal pathologists, vascular access coordinators, and dietitians (with 86%, 81%, and 78% of countries reporting a shortage, respectively), and the shortages were more common in low-income countries. Few countries (35%) reported a shortage in laboratory technicians. This information highlights significant inter- and intra-regional variability in the current capacity for kidney care across the world. Important gaps in awareness, services, workforce, and capacity for optimal care delivery were identified in many countries and regions.⁴ The findings have implications for policy development with regard to establishment of robust kidney care programs, particularly for low-income and lower-middle-income countries.⁴⁶ The Global Kidney Health Atlas has therefore provided a baseline understanding of where countries and regions stand with respect to several domains of the health system, thus allowing the monitoring of progress through the implementation of various strategies aimed at achieving equitable and quality care for the many patients with kidney disease across the globe.

How could this information be used to mitigate existing barriers to kidney care? First, basic infra-structure for services must be strengthened at the primary care level for early detection and management of AKI and CKD across all countries.⁴⁶ Second, although optimal kidney care obviously should emphasize prevention to reduce adverse consequences of kidney disease at the population level, countries (particularly low-income and lower-middle-income countries) should be supported at the same time to adopt more pragmatic approaches in providing RRT. For example, acute peritoneal dialysis could be an attractive modality for AKI, because this type of dialysis is as effective as hemodialysis, requires far less infrastructure, and can be performed with solutions and catheters adapted to local resources.⁴⁷ Third, kidney transplantation should be encouraged through increased awareness among the public and political leaders across countries, because this is the clinically optimal modality of RRT and it is also cost-effective, provided that costs of the surgery and long-term medication and follow-up are made sustainable through public (and/or private) funding.⁴⁸ Currently, most kidney transplants are conducted in high-income countries in part because of lack of resources and knowledge in low-income and lower-middle-income countries, as well as cultural practices and absence of legal frameworks governing organ donation.⁴⁸

Conclusion

Socially disadvantaged persons experience a disproportionate burden of kidney disease worldwide. The provision and delivery of kidney care varies widely across the world. Achieving universal health coverage worldwide by 2030 is one of the WHO Sustainable Development Goals. Although universal health coverage may not include all elements of kidney care in all countries (because this is usually a function of political, economic, and cultural factors), understanding what is feasible and important for a country or region with a focus on reducing the burden and consequences of kidney disease would be an important step toward achieving kidney health equity.

References:

1. GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1603-1658.
   CrossRef - PubMed
   
2. Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease–a systematic review and metaanalysis. PLoS One. 2016;11:e0158765.
   CrossRef - PubMed
   
3. Crews DC, Liu Y, Boulware LE. Disparities in the burden, outcomes, and care of chronic kidney disease. Curr Opin Nephrol Hypertens. 2014;23:298-305.
   CrossRef - PubMed
   
4. Bello AK, Levin A, Tonelli M, et al. Global Kidney Health Atlas: a report by the International Society of Nephrology on the current state of organization and structures for kidney care across the globe. https://www.theisn.org/images/ISN_advocacy/GKHAtlas_ Linked_Compressed1.pdf. Published 2017. Accessed August 22, 2018.
   CrossRef
   
5. Stanifer JW, Jing B, Tolan S, et al. The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Glob Health. 2014;2:e174-e181.
   CrossRef - PubMed
   
6. Davids MR, Eastwood JB, Selwood NH, et al. A renal registry for Africa: first steps. Clin Kidney J. 2016;9:162-167.
   CrossRef - PubMed
   
7. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1459-1544.
   CrossRef - PubMed
   
8. Liyanage T, Ninomiya T, Jha V, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. 2015;385:1975-1982.
   CrossRef - PubMed
   
9. Mehta RL, Cerda J, Burdmann EA, et al. International Society of Nephrology’s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet. 2015;385:2616-2643.
   CrossRef - PubMed
   
10. Samuel SM, Palacios-Derflingher L, Tonelli M, et al. Association between First Nations ethnicity and progression to kidney failure by presence and severity of albuminuria. CMAJ. 2014;186:E86-E94.
    CrossRef - PubMed
    
11. Nicholas SB, Kalantar-Zadeh K, Norris KC. Racial disparities in kidney disease outcomes. Semin Nephrol. 2013;33:409-415.
    CrossRef - PubMed
    
12. Van den Beukel TO, de Goeij MC, Dekker FW, Siegert CE, Halbesma N. Differences in progression to ESRD between black and white patients receiving predialysis care in a universal health care system. Clin J Am Soc Nephrol. 2013;8:1540-1547.
    CrossRef - PubMed
    
13. Crews DC, Gutierrez OM, Fedewa SA, et al. Low income, community poverty and risk of end stage renal disease. BMC Nephrol. 2014;15:192.
    CrossRef - PubMed
    
14. Garrity BH, Kramer H, Vellanki K, Leehey D, Brown J, Shoham DA. Time trends in the association of ESRD incidence with area-level poverty in the US population. Hemodial Int. 2016;20:78-83.
    CrossRef - PubMed
    
15. Parsa A, Kao WH, Xie D, et al. APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med. 2013;369:2183-2196.
    CrossRef - PubMed
    
16. Peralta CA, Bibbins-Domingo K, Vittinghoff E, et al. APOL1 genotype and race differences in incident albuminuria and renal function decline. J Am Soc Nephrol. 2016;27:887-893.
    CrossRef - PubMed
    
17. Correa-Rotter R. Mesoamerican nephropathy or chronic kidney disease of unknown origin. In: García- García G, Agodoa LY, Norris KC, eds. Chronic Kidney Disease in Disadvantaged Populations. Cambridge, MA: Academic Press; 2017:221-228.
    CrossRef
    
18. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1-150.
    
    
19. Chan JC, Gregg EW, Sargent J, Horton R. Reducing global diabetes burden by implementing solutions and identifying gaps: a Lancet Commission. Lancet. 2016;387:1494-1495.
    CrossRef - PubMed
    
20. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-223.
    CrossRef - PubMed
    
21. Plantinga LC, Miller ER 3rd, Stevens LA, et al. Blood pressure control among persons without and with chronic kidney disease: US trends and risk factors 1999-2006. Hypertension. 2009;54:47–56.
    CrossRef - PubMed
    
22. Banerjee T, Liu Y, Crews DC. Dietary patterns and CKD progression. Blood Purif. 2016;41:117-122.
    CrossRef - PubMed
    
23. Johnson AE, Boulware LE, Anderson CA, et al. Perceived barriers and facilitators of using dietary modification for CKD prevention among African Americans of low socioeconomic status: a qualitative study. BMC Nephrol. 2014;15:194.
    CrossRef - PubMed
    
24. Crews DC, Kuczmarski MF, Miller ER 3rd, Leehey D, Brown J, Shoham DA. Dietary habits, poverty, and chronic kidney disease in an urban population. J Ren Nutr. 2015;25:103–110.
    CrossRef - PubMed
    
25. Suarez JJ, Isakova T, Anderson CA, Boulware LE, Wolf M, Scialla JJ.Food access, chronic kidney disease, and hypertension in the U.S. Am J Prev Med. 2015;49:912–920.
    CrossRef - PubMed
    
26. Crews DC, Kuczmarski MF, Grubbs V, et al. Effect of food insecurity on chronic kidney disease in lower-income Americans. Am J Nephrol. 2014;39:27–35.
    CrossRef - PubMed
    
27. Banerjee T, Crews DC, Wesson DE, et al. Food insecurity, CKD, and subsequent ESRD in US adults. Am J Kidney Dis. 2017;70:38–47.
    CrossRef - PubMed
    
28. Piccoli GB, Alrukhaimi M, Liu ZH, Zakharova E, Levin A. Women and kidney disease: reflections on World Kidney Day 2018. Kidney Int. 2018;93:278–283.
    CrossRef - PubMed
    
29. Food and Agriculture Organization of the United Nations. The FAO hunger map 2015. http://www.fao.org/3/a-i4674e.pdf. Published 2015. Accessed August 22, 2018.
30. Shariff ZM, Khor GL. Obesity and household food insecurity: evidence from a sample of rural households in Malaysia. Eur J Clin Nutr. 2005;59:1049–1058.
    CrossRef - PubMed
    
31. Popkin BM. Contemporary nutritional transition: determinants of diet and its impact on body composition. Proc Nutr Soc. 2011;70:82–91.
    CrossRef - PubMed
    
32. Sawhney S, Marks A, Fluck N, Levin A, Prescott G, Black C. Intermediate and long-term outcomes of survivors of acute kidney injury episodes: a large population-based cohort study. Am J Kidney Dis. 2017;69:18-28.
    CrossRef - PubMed
    
33. Heung M, Steffick DE, Zivin K, et al. Acute kidney injury recovery pattern and subsequent risk of CKD: an analysis of Veterans Health Administration data. Am J Kidney Dis. 2016;67:742-752.
    CrossRef - PubMed
    
34. Grams ME, Matsushita K, Sang Y, et al. Explaining the racial difference in AKI incidence. J Am Soc Nephrol. 2014;25:1834-1841.
    CrossRef - PubMed
    
35. Luyckx VA, Tuttle KR, Garcia-Garcia G, et al. Reducing major risk factors for chronic kidney disease. Kidney Int Suppl. 2017;7:71-87.
    CrossRef - PubMed
    
36. Lewington AJ, Cerda J, Mehta RL. Raising awareness of acute kidney injury: a global perspective of a silent killer. Kidney Int. 2013;84:457-467.
    CrossRef - PubMed
    
37. Cervantes L, Tuot D, Raghavan R, et al. Association of emergency-only vs standard hemodialysis with mortality and health care use among undocumented immigrants with end-stage renal disease. JAMA Intern Med. 2018;178:188-195.
    CrossRef - PubMed
    
38. Rizvi SA, Naqvi SA, Zafar MN, Akhtar SF. A kidney transplantation model in a low-resource country: an experience from Pakistan. Kidney Int Suppl. 2013;3:236-240.
    CrossRef - PubMed
    
39. Roberti J, Cummings A, Myall M, et al. Work of being an adult patient with chronic kidney disease: a systematic review of qualitative studies. BMJ Open. 2018;8:e023507.
    CrossRef - PubMed
    
40. Kierans C, Padilla-Altamira C, Garcia-Garcia G, Ibarra-Hernandez M, Mercado FJ. When health systems are barriers to health care: challenges faced by uninsured Mexican kidney patients. PLoS One. 2013;8:e54380.
    CrossRef - PubMed
    
41. Murray CJ, Frenk J. A framework for assessing the performance of health systems. Bull World Health Organ. 2000;78:717-731.
    PubMed
    
42. Htay H, Alrukhaimi M, Ashuntantang GE, et al. Global access of patients with kidney disease to health technologies and medications: findings from the Global Kidney Health Atlas project. Kidney Int Suppl. 2018;8:64-73.
    CrossRef - PubMed
    
43. Osman MA, Alrukhaimi M, Ashuntantang GE, et al. Global nephrology workforce: gaps and opportunities toward a sustainable kidney care system. Kidney Int Suppl. 2018;8:52-63.
    CrossRef - PubMed
    
44. World Health Organization. Global Health Observatory indicator views. http://apps.who.int/gho/data/node.imr#ndx-P. Accessed August 22, 2018.
45. Harris DC, Dupuis S, Couser WG, Feehally J. Training nephrologists from developing countries: does it have a positive impact? Kidney Int Suppl. 2012;2:275-278.
    CrossRef - PubMed
    
46. Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. 2011;80:1258-1270.
    CrossRef - PubMed
    
47. Chionh CY, Soni SS, Finkelstein FO, Ronco C, Cruz DN. Use of peritoneal dialysis in AKI: a systematic review. Clin J Am Soc Nephrol. 2013;8:1649-1660.
    CrossRef - PubMed
    
48. Muralidharan A, White S. The need for kidney transplantation in low- and middle-income countries in 2012: an epidemiological perspective. Transplantation. 2015;99:476-478.
    CrossRef - PubMed