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Volume: 6 Issue: 4 November 2008 - Supplement - 1

FULL TEXT

QUALITY OF LIFE AFTER LIVER TRANSPLANTATION

Quality of life (QoL) has become a major focus after liver transplantation (LTx), since survival rates have improved dramatically over the past two decades. The EORTC QLQ C30 plus a liver transplant specific module were used to analyze QoL in 123 liver recipients (age 56.7±13.1 years; 70 male, 53 female) transplanted from 08/1992 to 06/2007. In addition, 40 listed patients awaiting LTx were included into the analysis. Uni- and multivariate analyzes was performed using SPSS13.0. The overall QoL in the liver recipient group was slightly but not significantly worse compared to a reference group of healthy individuals. However, the Global Health component of QoL in this group was better than in the group of waiting list patients (62.8±25.0 vs 52.1±26.5). This difference is statistically not significant due to the small number of waiting list patients, but might be considered as clinically significant. In comparison of the different primary diseases, post alcoholic cirrhotics had the same QoL as cholestatic patients. QoL was significantly decreased in patients with a liver retransplantation (re-LTx). In Conclusion, after establishing a system of continuous and systematic QoL assessments we report these results in combination with our survival results. Further research has to focus on advanced methodology of statistics combining these two major outcome parameters (quality of life and survival). Furthermore, the influence of medical parameters like co-morbidity or immunosuppression needs to be established on QoL.



Volume : 6
Issue : 4
Pages : 76


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Department of General- und Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany