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Volume: 6 Issue: 4 November 2008 - Supplement - 1

FULL TEXT

IS THERE ANY RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE AND OTHER PARAMETERS IN RENAL TRANSPLANTED PATIENTS?

Hyperhomocysteinemia seem to be frequent after renal transplantation. A cross-sectional analysis of 47 patients (30 males, 17 females) receiving unrelated living renal transplantation was carried out to determine the prevalence and important clinical and laboratory correlates of hyperhomocysteinemia. The mean total plasma homocysteine (Hcy) concentration was 21.7±8.4 (range, 5.8-48). Prevalence of hyperhomocysteinemia (Hcy ≥ 15miro mol/l) was 74 %( 37 patients). Serum Hcy was strongly related to BMI (r = 0.43, P = 0.002), cyclosporine trough level (r = 0.44, P = 0.005), and also associated with serum creatinine (r = 0.32, P = 0.028). There were no correlation between serum Hcy and age, duration of transplantation, and intima-media thickness of carotid artery. Serum Hcy in male was more than female (23.5 ± 9 vs 17 ± 6.3, P = 0.034). The frequency of hyper­homocysteinemia in patients receiving Cellcept was more than ones with Imuran (86% vs 44%, P = 0.017). There was no significant difference of serum Hcy level between diabetes and non diabetes. We conclude male obese transplanted patients with higher serum creatinine have higher serum Hcy level, and also Cellcept might increase serum Hcy. However, further studies should be done to confirm these results.



Volume : 6
Issue : 4
Pages : 41


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Department of Nephrology, Sadoughi Hospital, Shaheed Sadoughi University of Medical Sciences, and Azad University, Yazd, Iran