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Volume: 6 Issue: 4 November 2008 - Supplement - 1

FULL TEXT

SHORT-TERM AND LONG-TERM EFFECTS OF DELAYED GRAFT FUNCTION ON GRAFT SURVIVAL IN PEDIATRIC LIVE DONOR RENAL TRANSPLANTATION

Delayed graft function (DGF) generally has early and long term consequences for allograft survival. Limited studies have been performed about DGF and its complications in pediatric renal transplantation. Therefore, 230 children who received transplants between 1985 and 2005 in Labafi Nejad hospital were included in this study. DGF was defined if the serum creatinine level increased, remained unchanged, or decreased by less than 10% per day immediately after surgery during three consecutive days in first week after transplantation. The children were divided in two groups: 183 children in group A (Non DGF) and 47 patients in group B (DGF). The impact of DGF on renal function within the first year, long-term graft survival and post transplantation complications were analyzed and compared using Logistic regression model and Kaplan–Meier survival analysis. The incidence of graft failure at the end of follow-up period was significantly more common in DGF group (53.2% vs. 22.4%, P<0.001). The mean survival time was 134.20(SEM=6.17) months in group A (Non DGF) and 76.52(SEM=12.41) months in group B (DGF) (P<0.001). The graft survival rate was 94.9%, 91.9%, 83.9%, 79.2% and 72% at 1, 3, 5, 7 and 12 years after transplantation in children without DGF versus 75.6%, 53.2%, 47.2%, 31.9% at 1, 3, 5 and 8 years after transplantation in patients with DGF. The results of our study showed that delayed graft function could remarkably affect graft survival and worsen both short-term and long-term transplantation outcomes. Thus, the prevention of DGF is one of the most important issues in graft survival improvement.



Volume : 6
Issue : 4
Pages : 222


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*Pediatric Nephrology, Iran University of Medical Sciences and Health Services, Tehran, Iran