Ulcerative colitis (UC), an idiopathic disease with a likely immunological basis, is characterized by a lifelong chronic course with remissions and exacerbations. The combination of UC and end stage renal disease (ESRD) is uncommon. Immunosuppressive drugs, which are used after kidney transplantation, are considered as effective therapeutic alternatives for UC. We report two cases that had long term and symptomatic UC, confirmed by histological examination, before kidney transplantation. Clinical remission occurred immediately after operation, and they had no symptoms of ulcerative colitis during follow up periods (3 and 8 year). Their Immunosuppression regimens are cyclosporine, azathioprine/mycophenolate mofetil and prednisone. We think the improvement of UC in our patient can be attributed to using the immunosuppressive drugs, which have become the mainstay of therapy for the inflammatory bowel diseases. Kidney transplantation is a well-accepted treatment for patients with the inflammatory bowel diseases and end-stage renal disease.