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Volume: 6 Issue: 4 November 2008 - Supplement - 1

FULL TEXT

GENETIC POLYMORPHISMS IN THE GENES ENCODING HUMAN INTERLEUKIN-7 RECEPTOR-ALPHA: IN BONE MARROW TRANSPLANT RECIPIENTS

Interleukin-7 (IL-7) is essential for T-cell development in the thymus and for the maintenance of peripheral T cells. IL-7 signals through IL-7R, which consists of the gamma c-chain and an alpha-chain. Sequencing of IL-7Ralpha has revealed the existence of four single nucleotide polymorphisms (SNPs) (+510C/T, +1237 A/G, 2087T/C and +3110A/G), which all give rise to amino-acid substitutions. The aim of the present investigation was to evaluate the significance of IL-7Ralpha SNPs for the outcome in bone marrow stem cell transplantation (SCT). IL-7Ralpha polymorphisms were determined in 105 recipients from either matched sibling donors (40 patients) or outologus bone marrow transplants (66 patients). During 90 days follow up nine patients died (8.5%) and 23 patients had aGvHD (Grade I-III). None of the four IL-7Ralpha genotypes polymorphisms of the recipient was significantly associated with the outcome of SCT. Additional studies with larger sample are necessary to further define the influence of IL-7Ralpha on the immune response after BMT.



Volume : 6
Issue : 4
Pages : 204


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1Shiraz Transplant Research Center- Shiraz University of Medical Sciences-Shiraz –Iran.
2Department of Internal Medicine- Bone Marrow Transplant Center- Shiraz University of Medical Sciences-Shiraz-Iran.
3Hematology and Oncology Research Center- Shiraz University of Medical Sciences-Shiraz-Iran.