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Volume: 6 Issue: 4 November 2008 - Supplement - 1

FULL TEXT

IMPACT OF CARDIOVASCULAR RISK FACTORS ON THE OUTCOME OF RENAL TRANSPLANTATION

Cardiovascular diseases are more common in recipients of renal transplants and renal insufficiency has been shown to be a risk factor for cardiovascular disease. Reversely, some studies have reported that cardiovascular risk factors may interfere with the outcome of grafting. To determine the impact of cardiovascular risk factors on the outcome of renal transplantation in Iranian subjects. This is a retrospective, observational study including patients of 20-85 years of age who had undergone renal transplantation. Data collected included demographics, cardiovascular risk factors, past medical history, last measure of creatinine, cause of graft failure and death, date of transplantation, rejection, and death and the outcome of transplant. A total of 192 patients were analyzed including 152 cases and 40 controls. Frequencies for hypertension, hyper­lipoproteinemia, diabetes mellitus, obesity, cigarette smoking, and family history of cardiovascular diseases are available in the full text. The mean serum creatinine in the case and control groups were 1.33 ± 0.13 and 1.29 ± 0.36 mg/dL respectively (p-value=0.493). Response to transplantation was categorized based on a report from the World Health Organization. Complete response to grafting occurred in the control group more than the case group (p-value=0.009) while frequency of partial response to grafting was higher in the case group (p-value=0.008). A history of chronic obstructive pulmonary diseases (COPD) could significantly predict the outcome of grafting (p-value = 0.008) as could the occurrence of renal failure (p-value = 0.022). Results were consistently reproduced using multivariate cumulative log it model. In conclusion, The measured cardiovascular risk factors are apparently not related to the outcome of the transplantation



Volume : 6
Issue : 4
Pages : 136


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