Previous studies of renal transplantation in children have focused on the survival of grafts and patients. Little information is available about the cause of renal disease or the sources of donated organs. The aim of this study was organized to identify the diseases that require transplantation and to analyze factors that affect the success of transplantation in children. We collected data from pediatric hemodialysis center from 1997 to 2007. These data included information about demographic characteristics of patients, graft function and rate of graft rejection. Totally 242 children with end stage renal diseases were managed at our hemodiaysis center, and 53 children received renal transplantation during this period. Sixty-two percent of the transplanted kidneys came from a living donor (82% unrelated donor, 18% related donor), and 38 percent from a cadaver. The major diagnosis which caused renal failure and leading to transplantation were reflux nephropathy (28%), neurogenic bladder (15%), glomerulonphritis (13%), nephrolithiasis (9%) and nephrotic syndrome (5%). The mean age at transplantation was 13.1±1.1 years (min age: 4 years, max age: 24years). The rate of graft losses was 15% (living unrelated donor 3, living related donor 2 and cadaveric donor 3) and the mean time for graft failure was 6 months. During follow up, 2 patients died, and cancer developed in 2 patients. The most common causes of end-stage renal disease in children and adolescents in our center were reflux nephropathy and neurogenic bladder. The rates of graft survival were the same in patients who received a kidney from a living unrelated donor and those who received a kidney from a cadaver. Our study suggests that living related donor is superior to other options and must be encouraged whenever available.
Volume : 6
Issue : 4
Pages : 132
Mashhad University of Medical Scienses, Mashhad ,Iran.