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Volume: 6 Issue: 4 November 2008 - Supplement - 1

FULL TEXT

ROLE OF HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS FOR MONITORING THE BK VIRUS INFECTIONS IN HEMORRHAGIC CYSTITIS COMPLICATED BONE MARROW TRANSPLANT PATIENTS

Hemorrhagic cystitis (HC) is an important cause of morbidity and mortality in Bone Marrow Transplant (BMT) recipients .It’s incidence has varied from 7-70% in BMT patients .HC presentations are classified to early and late onset and one of the causative agents of HC late onset is viral infections. In this research for measuring the role BK virus (BKV) infections in late onset of HC, the prevalence of this viral infection in BMT recipients were determined .Also the role of another risk factors including: hematological and biochemical characteristics ,clinical conditions ,grade of GVHD in HC presentations were determined. We cohort and retrospectively studied 30 and 24 BMT recipients and donors respectively. The number of 293 EDTA treated blood samples and 293 urine samples were collected from BMT recipients and donors. One sample was collected pre-transplantation from BMT recipients and donors and also one sample per week for 100 days from BMT recipients post-transplantation BKV- monoplex in house PCR were proceed for determination of these viral prevalence in HC incidence in BMT patients .Also all the data of this investigation were statistically analyzed with version 12 of SPSS. The median incidence of HC in BMT recipients with measurement the grade of HC and with sonography records of bladder bleeding were 53.3% and 36.7% respectively .significant correlations were found between BKV -PCR positive results with HC presentation. Significant correlations were detected between hematological characteristics included: WBC and platelet counts and hemoglobin concentration and also biochemical characteristics like: creatinine, direct bilirubin and total bilirubin levels and liver function tests with BKV-PCR positive results and HC presentation. In conclusion, for significant correlations of HC clinical presentations with positive results of BKV-PCR and also with results of hematology and biochemical tests, monitoring of these parameters have a critical role in management of preventive and therapeutic protocols for HC disorder in BMT recipients.



Volume : 6
Issue : 4
Pages : 122


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1Shiraz Transplant Research Center- Shiraz University of Medical Sciences-Shiraz –Iran.
2Department of Internal Medicine- Bone Marrow Transplant Center- Shiraz University of Medical Sciences-Shiraz-Iran.
3Hematology and Oncology Research Center- Shiraz University of Medical Sciences-Shiraz-Iran