Both atherosclerosis and osteoporosis are responsible for significant morbidity and mortality, are independent predictors of cardiovascular disease in renal transplant recipients (RTRs). There is an inverse relationship between bone mineral density (BMD) and calcified coronary atherosclerosis. The aim of this study was the evaluation is BMD significantly associated with the presence of calcification in the carotid and coronary arteries in RTRs. We prospectively studied 25 (M=13,F=12) successfully RTRs with mean age of 38/05 ± 13.93& mean BMI: 24.1 ± 4.73& mean dialysis duration of 24.98 ± 17.67 and measured serum calcium, phosphate, alkaline phosphatase, blood urea & creatinine at baseline & monthly and iPTH & BMD & intimal medial thickening (IMT) of the common carotid artery & MDCT coronary CT for calcium scoring (cs) at baseline & 6 months after RTX. Lumbar BMD decreased from 0.900±0.16 to 0.812±0.11, (p<0.001) 6 month after RTX. There was also significant decrease of BMD of Femor & Radius (p<0.001) also T& Z score of Spine & Femor(p<0.002) 6 month after RTX. Mean total ca scoring was decreased significantly from pre RTX (41.64+/-58.05) to (26.14+/-37.36) post RTX p<0.001. There was linear & meaningful correlation between CS and iPTH & ca- p product reduction after RTX. There was no any linear regression between cs and BMD changes of Femor & Spine & Radius at month 6 after RTX. In conclusion, in early period after RTX significant improvement occurs in ca-p product & iPTH level & coronary calcification, but bone mass reduction is continued may be because of effect of immune suppressive drugs. We didn’t find any inverse relationship between BMD & calcification of coronary arteries in RTRs.
Volume : 6
Issue : 4
Pages : 101
Tabriz University of Medical Sciences, Tabriz, Iran